Water, pH and Ionic Equilibria

8/27/98


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NOTICE: This material is copyrighted and all right are reserved. (c) 1998 J. E. Wampler
Students may make a single copy for study purposes.

Table of Contents

{1} Water, pH and Ionic Equilibria

{2} WATER Structure & Properties

{3} A Water Model (versus book values):

{4} This model performs well

{5} Water is not your typical solvent*

{6} Water...

{7} Water...

{8} Key to much of the character of water is the H-bond.

{9} H-bond has a distinct, but small angle dependence

{10} Water also defines acids and bases

{11} This “equilibrium” constant...

{12} Ka’s...

{13} pKa...

{14} Acids, bases and amphoteric species

{15} Typical acids & bases:

{16} Some practical matters...

{17} Rearranged equation is not so simple...

{18} With amphoteric compounds...

Author: J. E. Wampler

Email: wampler@bchiris.bmb.uga.edu

Home Page: http://bmbiris.bmb.uga.edu/wampler/8010

Assignment:
Chapter 2 of Garrett and Grisham

References and Further Reading:
S.K. Burley and G. A. Petsko (1988), "Weakly Polar Interactions in Proteins," in Advances in Protein Chemistry vol. 39, pp. 125-189.

T. E. Creighton (1993), Proteins: Structure and Molecular Properties, W. H. Freeman and Co., New York, Chapter 4.

Edward Goo's lecture notes at USC

C. D. Hodgman, ed., Handbook of Chemistry and Physics (41st edition) (1959), Chemical Rubber Publishing Co., Cleveland, OH.

W. L. Jorgensen, J. Chandrasekhar and J. D. Madura (1983), "Comparison of Simple Potential Functions for Simulating Liquid Water," J. Chem. Phys. 79, 926-935.

I. Olovsson (1982), Croatica Chem. Acta 55, 171-190.