INSTRUCTORS:
Rebecca Terns
rterns(at)bmb.uga.edu
Michael Terns
mterns(at)bmb.uga.edu
ASSIGNMENTS:
January 26
Edith Hayden
Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells.
CANCER RESEARCH, 66 (11): 5763-5771 JUN 1 2006. Goldkorn, A; Blackburn, EH
Ting Yang
DNA Degradation at Unprotected Telomeres in Yeast Is Regulated by the CDK1 (Cdc28/Clb) Cell-Cycle Kinase.
Molecular Cell, Vol 24, 127-137, 06 October 2006. Momchil D. Vodenicharov1 and Raymund J. Wellinger.
February 2
Jason Carte
Deficiency of the zinc finger protein ZPR1 causes neurodegeneration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006 May 9;103(19):7471-5. Doran, B; Gherbesi, N; Hendricks, G; Flavell, RA; Davis, RJ; Gangwani, L
Priyanka Srivastava
Human RISC Couples MicroRNA Biogenesis and Posttranscriptional Gene Silencing.
Cell 2005 123: 631-640. Richard I. Gregory, Thimmaiah P. Chendrimada, Neil Cooch, and Ramin Shiekhattar.
February 9
Dusty Brown
Survival motor neuron function in motor axons is independent of functions required for small nuclear ribonucleoprotein biogenesis.
J Neurosci. 2006 Oct 25;26(43):11014-22. Carrel TL, McWhorter ML, Workman E, Zhang H, Wolstencroft EC, Lorson C, Bassell GJ, Burghes AH, Beattie CE.
Natalie Stephens
The gemin5 protein of the SMN complex identifies snRNAs.
MOLECULAR CELL, 23 (2): 273-279 JUL 21 2006. Battle, DJ; Lau, CK; Wan, LL; Deng, HY; Lotti, F; Dreyfuss, G.
February 16
Dianna Bourassa
Proteasome-dependent degradation of Est1p regulates the cell cycle-restricted assembly of telomerase in Saccharomyces cerevisiae.
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 13 (8): 720-728 AUG 2006. Osterhage, JL; Talley, JM; Friedman, KL
David Seidman
Human mRNA Export Machinery Recruited to the 5' End of mRNA
Cell, Vol 127, 1389-1400, 29 December 2006. Hong Cheng, Kobina Dufu,Chung-Sheng Lee,Jeanne L. Hsu, Anusha Dias, and Robin Reed
February 23
Shanda Birkeland
Telomere length homeostasis requires that telomerase levels are limiting.
EMBO JOURNAL, 25 (3): 565-574 FEB 8 2006. Cristofari, G; Lingner, J.
Tiffany Pottinger
Telomerase-independent Regulation of ATR by Human Telomerase RNA.
J Biol Chem. 2006 Dec 29;281(52):40503-14. Epub 2006 Nov 10. Kedde M, le Sage C, Duursma A, Zlotorynski E, van Leeuwen B, Nijkamp W, Beijersbergen R, Agami R.
March 9
Ting Yang
Crystal structure of an H/ACA box ribonucleoprotein particle.
NATURE, 443 (7109): 302-307 SEP 21 2006. Li, L; Ye, KQ
Ranjith Krishnankutty
Potential roles for ubiquitin and the proteasome during ribosome biogenesis.
MOLECULAR AND CELLULAR BIOLOGY, 26 (13): 5131-5145 JUL 2006. Stavreva, DA; Kawasaki, M; Dundr, M; Koberna, K; Muller, WG; Tsujimura-Takahashi, T; Komatsu, W; Hayano, T; Isobe, T; Raska, I; Misteli, T; Takahashi, N; McNally, JG.
March 23
Priyanka Srivastava
The Nuclear MicroSpherule Protein 58 is a novel RNA-binding Protein that Interacts with Fragile X Mental Retardation Protein in Polyribosomal mRNPs from neurons.
HUMAN MOLECULAR GENETICS, eFIRST date: 30 MAR 2006. Davidovic, L; Bechara, E; Gravel, M; Jaglin, XH; Tremblay, S; Sik, A; Bardoni, B; Khandjian, EW.
Edith Hayden
The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation.
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 13 (8): 734-739 AUG 2006. Eugster, A; Lanzuolo, C; Bonneton, M; Luciano, P; Pollice, A; Pulitzer, JF; Stegberg, E; Berthiau, AS; Forstemann, K; Corda, Y; Lingner, J; Geli, V; Gilson, E.
March 30
Natalie Stephens
gammaH2AX Dephosphorylation by Protein Phosphatase 2A Facilitates DNA Double-Strand Break Repair
Molecular Cell, Vol 20, 801-809, 09 December 2005. Dipanjan Chowdhury, Michael-Christopher Keogh, Haruhiko Ishii, Craig L. Peterson, Stephen Buratowski, and Judy Lieberman.
Jason Carte
Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly.
JOURNAL OF BIOLOGICAL CHEMISTRY, 281 (12): 8126-8134 MAR 24 2006. Carissimi, C; Saieva, L; Baccon, J; Chiarella, P; Maiolica, A; Sawyer, A; Rappsilber, J; Pellizzoni, L.
April 13
David Seidman
Regulating Gene Expression through RNA Nuclear Retention.
Cell 2005 123: 249-263. Kannanganattu V. Prasanth, Supriya G. Prasanth, Zhenyu Xuan, Stephen Hearn, Susan M. Freier, C. Frank Bennett, Michael Q. Zhang, and David L. Spector.
Dusty Brown
The Pyrococcus exosome complex - Structural and functional characterization.
JOURNAL OF BIOLOGICAL CHEMISTRY, 281 (10): 6751-6759 MAR 10 2006. Ramos, CRR; Oliveira, CLP; Torriani, IL; Oliveira, CC
April 20
Tiffany Pottinger
Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain.
MOLECULAR AND CELLULAR BIOLOGY, 26 (6): 2146-2159 MAR 2006. Middleman, EJ; Choi, JK; Venteicher, AS; Cheung, P; Artandi, SE
Dianna Bourassa
Identification, cloning, and functional analysis of the human U6 snRNA-specific terminal uridylyl transferase.
RNA-A PUBLICATION OF THE RNA SOCIETY, 12 (8): 1494-1504 AUG 2006. Trippe, R; Guschina, E; Hossbach, M; Urlaub, H; Luhrmann, R; Benecke, BJ.
April 27
Ranjith Krishnankutty
Stepwise RNP assembly at the site of H/ACA RNA transcription in human cells.
JOURNAL OF CELL BIOLOGY, 173 (2): 207-218 APR 24 2006. Darzacq, X; Kittur, N; Roy, S; Shav-Tal, Y; Singer, RH; Meier, UT
Shanda Birkeland
Regulation of Telomere Elongation by the Cyclin-Dependent Kinase CDK1
Molecular Cell, Vol 24, 423-432, 03 November 2006. Christopher J. Frank, Molly Hyde, and Carol W. Greider.
PAPERS FOR ORAL PRESENTATION:
Click on reference to link to abstract.
You may need to be on campus for links to function properly.
Email your top 4 choices to rterns(at)bmb.uga.edu by 11am January 9.
The first 4 scheduled presenters will receive first priority.
Otherwise the papers will be assigned first-come-first-served.
Assignments will be posted here.
Human PIF helicase is cell cycle regulated and associates with telomerase.
Cell Cycle. 2006 Dec;5(23):2796-804. Mateyak MK, Zakian VA.
Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis
Molecular Cell, Vol 24, 827-839, 28 December 2006. Yi Tang,1,2 Jianyuan Luo,1,2 Wenzhu Zhang,1,2 and Wei Gu
A comprehensive interaction map of the human SMN-complex.
J Biol Chem. 2006 Dec 18; [Epub ahead of print]. Otter S, Grimmler M, Neuenkirchen N, Chari A, Sickmann A, Fischer U.
Telomere and telomerase modulation by the mammalian Rad9/Rad1/Hus1 DNA-damage-checkpoint complex.
Curr Biol. 2006 Aug 8;16(15):1551-8. Francia S, Weiss RS, Hande MP, Freire R, d'Adda di Fagagna F.
Reconstitution, Activities, and Structure of the Eukaryotic RNA Exosome.
Cell 2006 127: 1223-1237. Quansheng Liu, Jaclyn C. Greimann, and Christopher D. Lima.
Relief of microRNA-Mediated Translational Repression in Human Cells Subjected to Stress.
Cell 2006 125: 1111-1124. Suvendra N. Bhattacharyya, Regula Habermacher, Ursula Martine, Ellen I. Closs, and Witold Filipowicz.
Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated Pathways.
Cell 2006 124: 343-354. Thomas F. Duchaine, James A. Wohlschlegel, Scott Kennedy, Yanxia Bei, Darryl Conte, KaMing Pang, Daniel R. Brownell, Sandra Harding, Shohei Mitani, Gary Ruvkun, John R. Yates, and Craig C. Mello.
The Mechanisms of PML-Nuclear Body Formation.
Molecular Cell, Vol 24, 331-339, 03 November 2006. Tian Huai Shen, Hui-Kuan Lin, Pier Paolo Scaglioni, Thomas M. Yung, and Pier Paolo Pandolfi.
Oligomerization behavior of the archaeal Sm2-type protein from Archaeoglobus fulgidus.
PROTEIN SCIENCE, 15 (10): 2310-2317 OCT 2006
Kilic, T; Sanglier, S; Van Dorsselaer, A; Suck, D.
FLASH is required for histone transcription and S-phase progression
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006 Oct 3;103(40):14808-12. Barcaroli, D; Bongiorno-Borbone, L; Terrinoni, A; Hofmann, TG; Rossi, M; Knight, RA; Matera, AG; Melino, G; De Laurenzi, V.
Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons.
JOURNAL OF NEUROSCIENCE, 26 (33): 8622-8632 AUG 15 2006. Zhang, HL; Xing, L; Rossoll, W; Wichterle, H; Singer, RH; Bassell, GJ
Genetic analysis of Myc and telomerase interactions in vivo.
MOLECULAR AND CELLULAR BIOLOGY, 26 (16): 6130-6138 AUG 2006. Flores, I; Evan, G; Blasco, MA.
Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies.
MOLECULAR BIOLOGY OF THE CELL, 17 (7): 3221-3231 JUL 2006.
Lemm, I; Girard, C; Kuhn, AN; Watkins, NJ; Schneider, M; Bordonne, R; Luhrmann, R.
Surveillance of nuclear-restricted pre-ribosomes within a subnucleolar region of Saccharomyces cerevisiae.
EMBO JOURNAL, 25 (11): 2662-2662 JUN 7 2006. Dez, C; Houseley, J; Tollervey, D.
Dynamic nature of cleavage bodies and their spatial relationship to DDX1 bodies, Cajal bodies, and gems.
MOLECULAR BIOLOGY OF THE CELL, 17 (3): 1126-1140 MAR 2006. Li, L; Roy, K; Katyal, S; Sun, XJ; Bleoo, S; Godbout, R.
Please let us know if you have trouble with any of the links from UGA computers.
