• 1989 B.S. in Microbiology from University of Central Florida, Orlando, FL
• 1993 M.S. in Molecular Biology and Microbiology, University of Central Florida, Orlando, FL
• 2001 Ph. D., Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA
• 2002-2003 Postdoctoral Associate, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA
• 2003-present Postdoctoral Associate, Complex Carbohydrate Research Center, University of Georgia (Prof. Kelley Moremen)
• Publications
1. Vandersall, A.S., Cameron, R.G., Nairn III, C.J., Yelenowsky, G., and Wodzinski, R.J. (1995) Identification, characterization, and partial purification of glucoamylase from Aspergillus niger (syn A. ficuum)NRRL 3135. Preparative Biochemistry 25, 29-55
2. Vandersall-Nairn, A. S., Merkle, R. K, O'Brien, K., Oeltmann, T. N., and Moremen, K.W. (1998) Cloning and expression of the lysosomal acid a-mannosidase of Trypanosoma cruzi. Glycobiology , 8, 1183-1194
3. Gonzalez, D. S., Karaveg, K., Vandersall-Nairn, A. S., Lal, A., and Moremen, K. W. (1999) Identification, expression, and characterization of a cDNA encoding human ER mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis. J. Biol. Chem., 274, 21375-21386.
• 1998 Won the Department of Biochemistry Graduate student poster competition.
• 2000 ARCS Foundation Scholarship for excellence in biomedical research.
• Outside Interests: gardening, cooking, dog showing

• 1989 B.S. in Department of Chemistry, Northeast Normal University, Changchun, 130024, P.R. China
• 1992 M.Sc. in Department of Chemistry, Northeast Normal University, Changchun, 130024, P.R. China
• 1995 Ph. D. in Department of Chemistry, Jilin University, Changchun, 130022, P.R. China
• 1995-1997 Postdoctoral fellow, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, P.R.China
• 1997-2000 Associate professor, Department of Chemistry, Northeast Normal University, Changchun, 130024 P.R.China
• 2000-2002 Postdoctoral Associate, Department of Chemistry and Biochemistry, Utah State University, Logan UT (Prof. Richard Holz)
• 2002-present Postdoctoral Associate, Complex Carbohydrate Research Center, University of Georgia (Prof. Kelley Moremen)
• Publications:
  1. V. M. D’souza, S. I. Swierczek, J. SeBok, N. J. Cosper, L. Meng, A. J. Copik, S. Ruebush, R. Scott, J. Peters and R. C. Holz, “Kinetics and Structural Characterization of  Manganese(II)-loaded Methionyl Aminopeptidases”. Biochemistry, 41(2002) 13096.2.
  2. L. Meng, S. Ruebush, V.M. D’souza, A. J.Copik, S. Tsunasawa, and R. C. Holz, “Over-expression and Divalent Metal Binding Properties of the Methionyl Aminopeptidase from Pyrococcus furiosus”, Biochemistry, 41 (2002) 7199.
  3. L. Meng andX.-P. Zhan,  “Synthesis characterization and properties of a-K7GaW11(TiO2)O39×11H2O heteropolyanion”, Trans. Met. Chem. 26 (2001) 448. 
  4. 4. L. Meng, X.-P. Zhan, M. Wang and J.-F. Liu,  “Synthesis 183W NMR spectroscopic characterization and properties of trisubstituted heteropolytungstates containing Group 3A elements”, Polyhedron 20 (2001) 881.
  5. J.-F. Liu, Y.-G. Chen, L.Meng, "Synthesis and characterization of novel heteropoly -tungstoarsenates containing lanthanides [LnAs4W40O140]25- and their biological activity" Polyhedron 9 (1998) 1541.
  6. L. Meng and Liu J.-F.,  "Synthesis and characterization of  a,b-triindium substitutedheteropolytungstates" Polyhedron 14(15) (1995) 2127.
  7. L. Meng and Liu J.-F.,  "Synthesis and characterization of a-P2W15M3O6212- (M=Ti,Zr) heteropolyanions" Trans. Met. Chem. 20 (1995) 188.
• Interests: Love to enjoy nature and all kind of sports even if not very good at them.

• Publications:
  1. Phillips RS, Chen HY, Shim D, Lima S, Tavakoli K, Sundararaju B (2004) Role of lysine-256 in Citrobacter freundii tyrosine phenol-lyase in monovalent cation activation . Biochemistry 43 :14412-14419.
  2. Martino PD, Fursy R, Bret L, Sundararaju B, Phillips RS (2003) Indole can act as an extracellular signal to regulate biofilm formation of Escherichia coli and other indole-producing bacteria . Can J Microbiol 49 :443-449.
  3. Demidkina TV, Barbolina MV, Faleev NG, Sundararaju B, Gollnick PD, Phillips RS (2002) Threonine-124 and phenylalanine-448 in Citrobacter freundii tyrosine phenol-lyase are necessary for activity with L-tyrosine . Biochem J 363 :745-752.
  4. Sundararaju B, Chen H, Shilcutt S, Phillips RS (2000) The role of glutamic acid-69 in the activation of Citrobacter freundii tyrosine phenol-lyase by monovalent cations . Biochemistry 39 :8546-8555.
  5. Koushik SV, Moore JA, 3rd, Sundararaju B, Phillips RS (1998) The catalytic mechanism of kynureninase from Pseudomonas fluorescens: insights from the effects of pH and isotopic substitution on steady-state and pre-steady-state kinetics . Biochemistry 37 :1376-1382.
  6. Phillips RS, Sundararaju B, Koushik SV (1998) The catalytic mechanism of kynureninase from Pseudomonas fluorescens: evidence for transient quinonoid and ketimine intermediates from rapid-scanning stopped-flow spectrophotometry . Biochemistry 37 :8783-8789.
  7. Koushik SV, Sundararaju B, McGraw RA, Phillips RS (1997) Cloning, sequence, and expression of kynureninase from Pseudomonas fluorescens . Arch Biochem Biophys 344 :301-308.
  8. Sundararaju B, Antson AA, Phillips RS, Demidkina TV, Barbolina MV, Gollnick P, Dodson GG, Wilson KS (1997) The crystal structure of Citrobacter freundii tyrosine phenol-lyase complexed with 3-(4'-hydroxyphenyl)propionic acid, together with site-directed mutagenesis and kinetic analysis, demonstrates that arginine 381 is required for substrate specificity . Biochemistry 36 :6502-6510.

Interests:

• Publications:
  1. Zheng Z, Butler KD, Tweten RK, Mensa-Wilmot K (2004) Endosomes, glycosomes, and glycosylphosphatidylinositol catabolism in Leishmania major . J Biol Chem 279 :42106-42113.
  2. Zheng Z, Tweten RK, Mensa-Wilmot K (2005) Intracellular glycosylphosphatidylinositols accumulate on endosomes: toxicity of alpha-toxin to Leishmania major . Eukaryot Cell 4 :556-566.
• Interests:

• Publications:
  1. Hering KW, Karaveg K, Moremen KW, Pearson WH (2005) A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum alpha-mannosidase I . J Org Chem 70 :9892-9904.
  2. Karaveg K, Siriwardena A, Tempel W, Liu ZJ, Glushka J, Wang BC, Moremen KW (2005) Mechanism of class 1 (glycosylhydrolase family 47) alpha-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control . J Biol Chem 280 :16197-16207.
  3. Karaveg K, Moremen KW (2005) Energetics of substrate binding and catalysis by class 1 (glycosylhydrolase family 47) alpha-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control . J Biol Chem 280 :29837-29848.
  4. Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (2005) Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins . Glycobiology 15 :421-436.
  5. Tempel W, Karaveg K, Liu ZJ, Rose J, Wang BC, Moremen KW (2004) Structure of mouse Golgi alpha-mannosidase IA reveals the molecular basis for substrate specificity among class 1 (family 47 glycosylhydrolase) alpha1,2-mannosidases . J Biol Chem 279 :29774-29786.
  6. Karaveg K, Liu ZJ, Tempel W, Doyle RJ, Rose JP, Wang BC (2003) Crystallization and preliminary X-ray diffraction analysis of lectin-1 from Pseudomonas aeruginosa . Acta Crystallogr D Biol Crystallogr 59 :1241-1242.
  7. Lobsanov YD, Vallee F, Imberty A, Yoshida T, Yip P, Herscovics A, Howell PL (2002) Structure of Penicillium citrinum alpha1,2-mannosidase reveals the basis for differences in specificity of the endoplasmic reticulum and Golgi class I enzymes . J Biol Chem 277 :5620-5630.
  8. Kawar Z, Karaveg K, Moremen KW, Jarvis DL (2001) Insect cells encode a class II alpha-mannosidase with unique properties . J Biol Chem 276 :16335-16340.
  9. Vallee F, Karaveg K, Herscovics A, Moremen KW, Howell PL (2000) Structural basis for catalysis and inhibition of N-glycan processing class I alpha 1,2-mannosidases . J Biol Chem 275 :41287-41298.
  10. Gonzalez DS, Karaveg K, Vandersall-Nairn AS, Lal A, Moremen KW (1999) Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis . J Biol Chem 274 :21375-21386.
• Interests:

• 1994 B. S. in Biological Sciences from Wayne State University, Detroit, MI
• 2000 M. S. in Biological Sciences from Wayne State University, Detroit, MI
• 2000 Entered Ph. D. Program, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA
• 2000 Joined Dr. Moremen’s lab
• 2002 Glycobiology Meeting in Boston, MA
• 2004 Appointed Faculty Liason for the Biochemistry Student Graduate Association (BSGA)
• 2004 Glycobiology Meeting in Honolulu, HI
• Current Research: Studying the Role of a–Mannosidase IIx in Animal Development

• 2001 B.S. in Molecular and Microbiology from University of Central Florida, Orlando, FL
• 2002 Joined Moremen laboratory
• 2003 Entered M.S. program, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA
• Publications:   
  1. Park C, Meng L, Stanton LH, Collins RE, Mast SW, Yi X, Strachan H, Moremen KW (2005) Characterization of a human core-specific lysosomal alpha1,6-mannosidase involved in N-glycan catabolism . J Biol Chem 280 :37204-37216.
  2. Siriwardena A, Strachan H, El-Daher S, Way G, Winchester B, Glushka J, Moremen K, Boons GJ (2005) Potent and selective inhibition of class II alpha-D-mannosidase activity by a bicyclic sulfonium salt . Chembiochem 6 :845-848.
  3. Li B, Kawatkar SP, George S, Strachan H, Woods RJ, Siriwardena A, Moremen KW, Boons GJ (2004) Inhibition of Golgi mannosidase II with mannostatin A analogues: synthesis, biological evaluation, and structure-activity relationship studies . Chembiochem 5 :1220-1227.        
• Abstracts:
  1. George, S., Li, B., Strachan, H., Ayers, R., Collins, R., Siriwardena, A., Moremen, K.W., and Boons, G.-J. (2002) Development of selective inhibitors of processing and catabolic Class 2 (family 38 glycosyl hydrolase) a-mannosidase: synthesis and evaluation of mannostatin derivatives. Glycobiology, 12, 668
  2. Stanton, C., Magnum, J., Strachan, H., Ayers, R., Collins, R., Boons, G.-J., Moremen, K.W., and Siriwardena, A. (2002) Design and synthesis of sulfonium salts and azasugar analogs of swainsonine as selective inhibitors of processing and catabolic Class 2 (family 38 glycosyl hydrolase)  a-mannosidases. Glycobiology, 12,
• Outside interests: hiking, cooking, gardening, and music

• Publications:
• Interests:

• Publications:
• Interests:

• B.A. in History from University of Georgia, Athens, GA
• Ph. D. School of Hard Knocks and Bitter Disappointment (?!)
• Outside Intests: cooking, gardening, reading, winning the lottery
• "she keeps everything running smoothly"