Dr. Michael W.W. Adams (Life Sciences, Rm. B218.  Tel:  542-2060. adams@bmb.uga.edu)
1. Growth, physiology, metabolism and enzymology of organisms growing near 100°C from deep-sea hydrothermal vents, including the use of DNA microarray analyses and proteomics to study Pyrococcus furiosus.

Drs. Peter Albersheim/Alan Darvill (Complex Carbohydrate Research Center, Riverbend Road. Tel: 542-4411.  adarvill@ccrc.uga.edu). 
1.  Structure and function of plant cell wall polysaccharides. 2. Oligosaccharin bioactivity studies 3. Development of methods for carbohydrate structural analysis.

Dr. Maor Bar-Peled (Complex Carbohydrate Research Center, Riverbend road; Tel: 542-4496. peled@ccrc.uga.edu)
1. Cloning genes, mutagenesis, and biochemical characterization of recombinant enzymes that control synthesis of glyco conjugates in human pathogen fungus and in plants. 2. Cell biology: molecular mechanism for localization of membrane bound proteins to ER and Golgi. 3. Genetics: analyses of mutants affecting polysaccharide synthesis. 4. Isolation of protein complexes.

Dr. Carl W. Bergmann (Complex Carbohydrate Research Center, Riverbend Road.  Tel:  542-4487.  cberg@ccrc.uga.edu).
1. Combination of biochemistry, surface plasmon resonance spectrometry, and mass spectrometry for investigation of the structure and function of the proteins that interact with anionic extracellular matrix polysaccharides in plants and animals.

Dr. John Brewer (Life Sciences, Rm. A316.  Tel: 542-1773.  brewer@bmb.uga.edu)
1.  Protein folding/subunit dissociation in proteins using sedimentation equilibrium and/or differential scanning calorimetry.

Dr. Clanton Black (Life Sciences, Rm. A314:  Tel:  542-1778.  ccblack@bmb.uga.edu)
1.  Xanthophyll cycle of photoprotection in trees (involves pigment isolation, analyses of reductants, and HPLC analyses).  2.  Daily variations in Crassulaceon acid metabolism (involves titrations and enzyme assays).

Dr. Russell W. Carlson (Complex Carbohydrate Research Center, Riverbend Road.  Tel: 542-4439.  rcarlson@ccrc.uga.edu)
1.  Characterization of bacterial surface glycoconjugates in determining the virulence of bacterial pathogens (and symbionts) of plants and animals.

Dr. Harry A. Dailey (Coverdell Building.  Tel: 542-2690.  hdailey@uga.edu)
1. Structure - function studies of the enzymes of heme biosynthesis  2. Regulation of mammalian heme biosynthesis

Dr. Stephen Dalton (Coverdell Building.  Tel: 583-0480. sdalton@uga.edu)
The biology of embryonic stem cells and their diferentiation into cell types that have applications for curing diseases such as diabetes.

Dr. Jeffrey F.D. Dean (Old CCRC, Rm. 145. Tel: 542-1710. jeffdean@uga.edu)
1. Biochemical and molecular characterization of multicopper oxidases. 2. Iron uptake in plant and bacterial systems.  3. Functional genomic approaches to understanding tree growth and development.  4. Environmental genomics and phytoremediation.

Dr. Daniel V. DerVartanian (Life Sciences, A220A.  Tel: 542-1693. dervar@bmb.uga.edu)
Characterization of nickel-containing enzymes from heart and clinical implications. 

Dr. Claiborne Glover III (Life Sciences, Rm. A410. Tel:  542-1769. glover@uga.edu)
Protein phosphorylation in the budding yeast, Saccharomyces cerevisiae, using biochemical, molecular, genetic, and genomic approaches.

Dr. Michael G. Hahn (Complex Carbohydrate Research Center, 315 Riverbend Road; Tel: 542-4457; hahn@ccrc.uga.edu)
1.  Generation and characterization of monoclonal antibodies against plant cell wall polysaccharides.  2. Characterization of proteins encoded by a family of genes related to enzymes involved in the biosynthesis of pectic polysaccharides in plant cell walls. 3. Studies of plant signal transduction pathways induced by biologically-active oligosaccharides.

Dr. Stephen Hajduk  (Life Sciences, Rm B128. Tel: 542-1676. shajduk@bmb.uga.edu)
1.  Function and Regulation of RNA editing in African trypanosomes. 2. Mechanism of human serum high density lipoprotein killing of African trypanosomes. 3. RNA and protein import into mitochondria. 

Dr. William N. Lanzilotta (Life Sciences, A130. Tel: 542-1573. wlanzilo@bmb.uga.edu)
1.  Structure/function investigation into the mechanism of heme uptake and transport by enteric pathogens.  2. The role of iron-sulfur clusters in radical chemistry: Biochemical and structural analysis of the1,3-propanediol pathway from Clostridium acetobutylicum.

Dr. John Lee (Life Sciences, Rm. A120A.  Tel: 542-1764. jlee@uga.edu)
1.  Analysis of NMR data on protein structure.  2.  Fluorescence methods for analyzing protein interactions.  3.  Analysis of bioluminescence reactions.

Dr. Debra Mohnen (Complex Carbohydrate Research Center, 315 Riverbend Road. Tel: 542-4458. dmohnen@ccrc.uga.edu)
1.  Purification, characterization, and cloning of glycosyltransferases involved in the biosynthesis of pectin, a plant cell wall polysaccharide required for plant growth and development and with beneficial effects on human health and commercially important functions in the food industry. 2.  Studies on the role of the GAUT1-related gene family in plant cell wall synthesis and implications for enhancing biofuel production. 3. Studying the molecular basis for the anti-cancer effects of pectin.

Dr. Kelley Moremen (Complex Carbohydrate Research Center, 315 Riverbend Rd., Rm 3055 Tel: 542-1705. moremen@uga.edu)
1. Expression and characterization of mammalian enzymes and lectins involved in glycoprotein biosynthesis and degradation. 2) Structure-function studies on glycoprotein processing enzymes including biochemical, kinetic, and structural studies. 3. Transcript analysis and gene regulation of glycan-related genes.

Dr. Ron Orlando (Complex Carbohydrate Research Center, 220 Riverbend Road.  Tel: 542-4429. orlando@ccrc.uga.edu)
1. Proteomics. 2. Mass Spectrometry. 3. Identifying post-translational modifications on proteins

Dr. Robert Phillips (Chemistry, Room 313.  Tel:  542-1996. rsphillips@chem.uga.edu)
1.  Isolation of wild-type and mutant enzymes and comparison of kinetic properties.  Students may also perform site-directed mutagenesis to prepare new mutant enzymes.

Dr. James Prestegard (Complex Carbohydrate Research Center, 220 Riverbend Road. Tel: 542-6281. jpresteg@ccrc.uga.edu)
NMR spectroscopy with applications to proteins and carbohydrates.  Projects involve protein expression and protein purification, NMR of carbohydrates, and development of new media for NMR studies.

Dr. Michael Pierce (Life Sciences, Rm. B314B.  Tel:  542-1702 email:  hawkeye@uga.edu)
1.  Investigation of members of a new family of animal lectins that have physiological functions in humans. 2.  Effects of glycosylation on tumor cell adhesion, invasion, and tumorigenicity.   3. Discovery of of novel glycosyltransferases.

Dr. J. David Puett (Life Sciences, Rm. B302B. Tel: 706-542-0004: puett@bmb.uga.edu)
1. Molecular and cell biology of reproductive G protein-coupled receptors: ligand binding, receptor activation, and G protein coupling. 2. Cancer biology with emphasis on cancer cell response to growth factors: growth properties, gene expression, and proteomics

Dr. John Rose (Life Sciences, Rm. B204B.  Tel: 542-1750.  rose@bcl4.bmb.uga.edu)
Structural Biology, structure function studies of the Augmenter of  Liver Regeneration and its cellular partners; structure function 
studies of the oxytocin receptor; structure function studies of HIV ˆ host protein complexes; soft x-ray phasing of macromolecular structures

Dr. Robert Sabatini (Life Sciences, Rm A128B. Tel:  542-9806. rsabatini@bmb.uga.edu)
1.  Characterization of enzymes involved in the glucosylation of telomeric DNA in kinetoplatids.  2.  Investigate the biological role of DNA glucosylation in telomeric gene expression/recombination in African trypanosomes.

Dr. Walter K. Schmidt (Life Sciences, Rm. A416. Tel : 583-8241. wschmidt@bmb.uga.edu)
1. Characterization of Rce1p, a protease having a regulatory role in cellular transformation/cancer.  2.  Characterization of Ste23p, the yeast ortholog of a protease involved in Alzheimer's disease.

Dr. Robert A. Scott (Chemistry, Rm. 679: Tel: 542-2240.  scott@chem.uga.edu)
1. Cloning and expression of transcription factors from archaea and eucarya; biophysical characterization of gene products.  2. Proteomic discovery of regulatory transcription factors in hyperthermophilic archaea.

Dr. Richard Steet (Complex Carbohydrate Research Center, 315 Riverbend Road, rm. 3034 Tel: (706) 583-5550.  rsteet@ccrc.uga.edu)
1. Role of the mannose 6-phosphate targeting pathway in development and disease. 2. Zebrafish models of lysosomal storage disorders. 3. Discovery and characterization of novel glycosylation disorders.

Dr. Rebecca Terns (Life Sciences, Rm. A326. Tel: 542-1703. rterns@bmb.uga.edu)
Cloning genes encoding proteins that interact with an RNA using 2- and 3-hybrid screens.  Involves molecular biology (PCR, sequence analysis, restriction analysis, subcloning, DNA purification) and microbiology (yeast and bacteria culturing).

Dr. Michael Terns (Life Sciences, Rm. A308B.  Tel: 542-1896. mterns@bmb.uga.edu)
1.  Cloning and sequencing of genes encoding RNA-binding proteins.  2.  Analysis of RNA/protein interactions.

Dr. Michael Tiemeyer (Complex Carbohydrate Research Center, 220 Riverbend Road, 542-2740, mtiemeyer@ccrc.uga.edu) 1. Structure and function of carbohydrates that direct cell-cell interactions during nervous system development in Drosophila. 2. Genetic control of tissue-specific glycan expression, 3. Comparative glycomics and proteomics of model organisms.

Dr. Jeffrey Urbauer (Life Sciences, Rm. A310, Tel: 542-7922. urbauer@chem.uga.edu)
1.  Protein structure and stability using NMR spectroscopy.    2.  Analysis of protein-protein interactions using biophysical and in vivo techniques.    3.  Characterization of oxidation-induced structural and functional changes in proteins.

Dr. Bi-Cheng (B.C.) Wang (Life Sciences, Rm. B204A.  Tel: 542-1747. wang@bcl1.bmb.uga.edu)
Protein crystallography

Dr. Lianchun Wang (Complex Carbohydrate Research Center, 315 Riverbend Road, Rm. 3005. Tel: 542-6445. <Lwang@ccrc.uga.edu>Lwang@ccrc.uga.edu)
 The role and structure-function relationship of heparan sulfate in vascular development and blood coagulation.

Dr. Lance Wells (Complex Carbohydrate Research Center, 220 Riverbend Road, 542-7806. lwells@ccrc.uga.edu)
1. Insulin Signal Transduction and Type II Diabetes, 2.  Nutrient Sensing and Oncogenesis, 3. Proteomics and Site-Mapping by Mass Spectrometry of Post-translational Modifications in Disease States."

Dr. Juergen Wiegel (Biological Sci., Rm. 212c.  Tel:  542-2651. (jwiegel@ uga.edu)
1. Analyzing hypothetical proteins from genome sequences for predicted enzymatic activity for a novel family of aerobic and anaerobic phenolic carboxylase / arylic acid decarboxylase, including characterizing recombinant proteins for crystallographic analysis.  2. Isolation of novel iron-reducing, hydrogen-utilizing anaerobic thermophiles from an alkaline soil of Nevada

Dr. William B. Whitman (Biological Sci., Rm. 541.  Tel:  542-4219. whitman@uga.edu)
1. Isolation and characterization of soil bacteria.  2.  Genetics and physiology of methanogenic archaea.

Dr. Robert J. Woods (Complex Carbohydrate Research Center, 220 Riverbend Road, 542-4454.  rwoods@ccrc.uga.edu).
Molecular simulations of proteins and carbohydrate-protein complexes of immunological relevance.

Dr. William S. York (Complex Carbohydrate Research Center, 220 Riverbend Road, 542-4628. will@ccrc.uga.edu) 
1. Bioinformatics of cell surface glycans in developing animal cells.  2. The roles of complex cell wall polysaccharides in plant development.

Dr. Ying Xu (Life Sciences, Rm A110, Tel: 542-9779, xyn@bmb.uga.edu)
1. Computational structural biology. 2. Computational inference and reconstruction of biological pathways and networks. 3.   Biological data mining.

Dr. Shaying Zhao (Life Sciences, Rm. B316. Tel: 542-9147. E-mail: szhao@bmb.uga.edu)
1. Microssatellite instability detection in cancer samples. 2. Gene expression alternation in cancer development and progression. 3. Gene expression alternation due to genomic rearrangements during evolution.