| Orlando,
Ron |
E-mail:
orlando@ccrc.uga.edu |
| My
research focuses on the use of mass spectrometry to answer biological
/ biomedical questions. The majority of our projects involve
characterizing the post-translational modifications (e.g., glycosylation,
phosphorylation) present in the protein of interest. For example,
we are currently investigating the in vivo changes that occur
in human eye lenses upon normal aging and cataract formation.
We hope that this research ultimately will provide a mechanism
to prevent cataracts. We also conduct research into developing
new methodologies to increase the amount of information obtained
from these MS experiments and to reduce the quantity of material
needed for analysis. |
| Keywords:
mass spectrometry, MS, characterization of post-translational
modifications, protein glycosylation, proteomics, protein identification,
liquid chromatography, LC/MS, matrix-assisted laser desorption
/ ionization MS, MALDI-MS, MS/MS |
|
| Wells, Lance |
E-mail: lwells@ccrc.uga.edu |
| Our broad research interest is in understanding how post-translational modifications modulate the properties of proteins. Specifically, we study "nutrient sensing" by characterizing the enzymes responsible for post-translational modification of proteins that have been implicated in responding to nutrients and regulating signal transduction cascades. Our lab uses a combination of methodologies including mass spectrometry, protein biochemistry, cell biology, proteomics, and molecular biology. We perform our experiments in vitro, in mammalian cell culture systems, and in the model organism C. elegans. We are currently focusing on the regulatory role of glycosylation in the development of type II diabetes, cancer, and congenital muscular dystrophy. |
| Keywords: glycosylation, phosphorylation, mass spectrometry, proteomics, signal transduction, diabetes, cancer, protein biochemistry |
|
|
